I'm sure we'll see Ridley Scott direct an episode or two. I wouldn't be surprised if his son Luke directed some, as he did two of the BR short films (and some Raised By Wolves, which I still need to watch at some point). Whether Villeneuve would be involved I guess would depend on when it goes into production. He's probably got his hands completely full with Dune: Part Two for the next year. But I'm also not sure if he's the type of director to take on one episode of a TV series unless it was the pilot, which I'm sure is reserved for Ridley.
As for the showrunner, Silka Luisa, the only thing I've seen that she's been involved with is the Halo show... which I really did not like. But her other work seems decent, so I'm not too worried there.