The first thing I must point out is that several online sources (and the book's own 'About the Author' section) claim that these books reconcile the differences between Do Androids Dream of Electric Sheep? and Blade Runner. This is just completely false and baffling why anyone would think that. They're clearly sequels to Blade Runner, but with some unused elements of DADOES thrown in. Nothing major like Mercerism, radioactive dust, specials, or animal ownership. Just minor stuff like the U.N., the Salander 3, and a character named Isidore (who is now separate from Sebastian).
But the thing I dislike most about the book is what it does to several characters from the film. Gaff unceremoniously dies, Bryant dies in the first chapter, Sebastian is no longer dead, Rachael does absolutely nothing in this book except sleep and die (unless I'm forgetting something; I'm barely into my re-read so far), and we will get to Pris when I get there in my re-read. But just to make it clear, I absolutely hate what Jeter did to Pris. Just look at her Jeter article and you'll see what I mean.