After Bryant's top Blade Runner, Dave Holden, was shot and critically wounded by the replicant Leon, Bryant sent Gaff out to "arrest" Deckard and bring him to Bryant. While Bryant at first made attempts to be friendly, their meeting soon boiled down to pure business as he briefed Deckard on the replicants that he needed to take down: Leon, Zhora, Pris and Roy Batty. While briefing Deckard, he mistakenly told him that only one replicant from the group had died, apparently leaving another unaccounted for.
Bryant and Gaff later met Deckard near a streetside bar after he retired Zhora. Bryant was more friendly to Deckard, boasting to Gaff that he could learn from him. However, his lack of humanity in regard to Zhora's death and the effect it had Deckard was noticeable. He also informed Deckard that he now needed to retire the experimental replicant Rachael, who had gone rogue after learning her true replicant identity. He then wished Deckard good luck and left the bar.
Following Gaff's death while on assignment, Bryant attended the funeral, showing distaste for the gravestone's Cityspeak epitaph. As part of a plot to destroy the Tyrell Corporation, Sarah Tyrell killed Bryant and made it seem that he removed files of the renegade group's sixth replicant. Deckard met Bryant in his office, though Bryant was displayed as video to him, claiming to be in the hospital with an infection. Deckard soon realized that the image was a persynth.