Las Vegas was a city in the state of Nevada, United States. Sometime before 2049, it became uninhabitable due to a dirty bomb going off and dousing the city with harmful radiation.
The Las Vegas of 2049 retained much of its earlier appearance before a dirty bomb forced all living things to vacate the city. Classic Las Vegas landmarks such as the copies of the Pyramids and the Eiffel Tower were surrounded by newer architecture. Like Los Angeles, the streets moved vertically, where the poor and homeless lived at the "basement" of the city, while those who could afford it stayed higher up.
In the time between the 2022's Blackout and 2049, the radiation levels in the city had lowered to a nominal level, but it remained deserted. During this time, ex-Blade Runner Rick Deckard moved into Las Vegas to live in seclusion after working with Freysa and the replicant resistance movement to hide the child he had with Rachael. At some point, he acquired a dog.