The Las Vegas of 2049 retained much of its earlier appearance before a dirty bomb forced all living things to vacate the city. Classic Las Vegas landmarks such as the copies of the Pyramids and the Eiffel Tower were surrounded by newer architecture. Like Los Angeles, the streets moved vertically, where the poor and homeless lived at the "basement" of the city, while those who could afford it stayed higher up.
In the time between the 2022's Blackout and 2049, the radiation levels in the city had lowered to a nominal level, but it remained deserted. During this time, ex-Blade RunnerRick Deckard moved into Las Vegas to live in seclusion after working with Freysa and the replicant resistance movement to hide the child he had with Rachael. At some point, he acquired a dog.
Following K's discovery of Deckard in Las Vegas, Deckard justified this decision to live as a recluse with keeping his daughter safe and free of persecution, revealing: "We were being hunted."