Spencer Grigorian is the leader of CARS, Citizen Against Replicant Slavery, and has been taken into custody by Crystal Steele as a suspect in a bombing attack against Tyrell Corporation, Spencer having led a rally against Tyrell in the vicinity at the time of the attack. Spencer likens his activities with CARS to the operation of the 19th century Underground Railroad, viewing himself as a freedom fighter and a champion for the cause of the replicants.

During the events of the game, Ray McCoy can question him and administer a Voight-Kampff test, this serving as a tutorial for the player on the operation of the VK machine.